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綠意生活 Green Life info ★ 實用生活資訊 Update: 2021/12/07
?? This article uses auto translate to English, so it’s not so fluent. We will make a correction soon. Thanks for your reading ??
Before understanding the theories of vaccines, it's is better to understand DNA and RNA→ 【Spiral DNA and RNA of life】 ．【DNA Shadow Doppelganger Art-RNA】
→【DNA? RNA? It turns out to be such a relationship!】
The main sources of vaccine-related information in this article
Ministry of Health and Welfare-Introduction to COVID-19 Vaccines
GAVI The Vaccine Alliance
GENE ONLINE – Four major COVID-19 vaccines
USA Centers for Disease Control and Prevention (CDC)
The following is the summary and key points, so that readers can understand the principle of the vaccine, and evaluate the suitable vaccine according to personal physique, history of allergies, chronic diseases and other physical conditions.
Types, characteristics, and possible side effects of COVID-19 vaccine
GAVI The Vaccine Alliance
How safe are COVID-19 vaccines?
COVID-19 vaccine type: Viral vector | Nucleic acid | Protein subunit | Whole virus
Modena - and - Pfizer both are based on mRNA technology new-type vaccines. There has not been a record of public use before the new crown epidemic, but they have undergone more than ten years of research and development. RNA is responsible for copying, transmitting, and deducing the genetic code of DNA in cells. mRNA (messenger RNA) is a type of RNA (there are three types of RNA: mRNA, rRNA, and tRNA), which is responsible for conveying messages to cells and instructing the cells to make what protein.
The mRNA vaccine uses this principle to encapsulate the mRNA of the replicated new coronavirus in nano-lipid particles and inject it into the human body. The cells will begin to produce an outer membrane of spinous protein similar to the new coronavirus, which then triggers an immune response and produces antibodies.
The mRNA vaccine cannot enter the center of the nucleus of human cells to contact the DNA, and it will not change the DNA. The viral RNA will disintegrate within 72 hours and will not remain in the human body.
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Kuon.Haku, CC BY 4.0 , via Wikimedia Commons
Johnson & Johnson 、AZ both are based on non-replicating adenovirus vaccine vector (adenoviral vector vaccine）, is the use of "harmless, a modified virus" as a carrier having "an antigen for producing" genetic material DNA is transferred to the instruction In human host cells, the nucleus transcribes this DNA into RNA, and the RNA transforms into mRNA. The mRNA allows the somatic cells to start producing viral spike proteins, triggering an immune response and producing antibodies.
The non-replicating and modified virus itself does not have the new coronavirus antigen (thorn protein), nor can it replicate the virus in the body. The principle is to allow the body to produce new coronavirus antibodies through a one-time simulated infection (not causing disease).
Regarding the cause of thrombosis in the vaccine, there are research papers that have not yet been tested on humans :●→Thesis link
【UDN Yuanqi Net-Scientific Health Care / Professor Lin Qingshun's Article】The latest research reveals: why the adenovirus vaccine may cause thrombosis, mRNA vaccine But not?
Adenovirus vector vaccines produce spike protein mRNAs of different lengths and different combinations through DNA transcription. Some of them have free and soluble spike protein variants, which may be combined with ACE2 of vascular cells along with the blood circulation. Coupled with the participation of antibodies, it is possible to cause thrombosis.
mRNA vaccine - and - adenovirus vector vaccine What is the difference？
mRNA vaccinedirectly uses replicated viral mRNA (instruction to make viral spike protein). The mRNA is very weak, short-lived, and difficult to preserve. It will be eliminated by the cell within about 72 hours after entering the human body.
adenovirus vector vaccineuse "harmless and modified adenovirus" as a carrier, and then put a piece of RNA or DNA that makes the viral spike protein into the adenovirus gene sequence. This modified virus is not a new coronavirus, and* it does not have a new coronavirus antigen (spine protein). It will also use mRNA to allow somatic cells to make spine protein by themselves.
adenovirus vector vaccine are more stable than mRNA vaccine and can be stored at 2°C to 8°C for 6 months, which is more conducive to long-term storage and transportation. Can trigger a strong immune response. The development of vaccine technology is relatively mature. The manufacturing process is more complicated.
mRNA vaccine advantage is that it *does not contain live virus components, has a lower manufacturing cost and can be manufactured more quickly. However, the storage conditions are more demanding, and it must be frozen at low temperature (Modena below -20°C / 6 months, Pfizer-70°C / 1 year). It is a new type of vaccine, and there has never been a license for human administration (LICENSE) before the new crown epidemic.
Unlike traditional vaccines (whole virus vaccines ..Protein subunit vaccines），adenovirus vector vaccine - and - mRNA vaccine both are based on "antigen-free" , allowing somatic cells to produce antigens without actually being infected and causing disease (new crown The coat spine protein of the virus), which triggers an immune response.
Katie L. Flanagan, Emma Best, Nigel W. Crawford, Michelle Giles, Archana Koirala, Kristine Macartney, Fiona Russell, Benjamin W. Teh, and Sophie CH Wen, on behalf of the Australasian Society for Infectious Diseases (ASID) Vaccination Special Interest group (VACSIG), CC BY 4.0 , via Wikimedia Commons
●→ COVID-19 publicly funded vaccine reservation platform ( Taiwan )
following source of vaccine imitation information is from : Ministry of Health and Welfare Website-Vaccine Profile
AZ, Modena, Pfizer BNT, and high-end. All four vaccines will* not change human DNA. They do *not contain reproducible SARS-CoV-2 virus particles and will not suffer from COVID-19 due to vaccination .* in the next few months .
AZ ( AstraZeneca ) is a *non-replicating adenovirus vector vaccine* containing the SARS-CoV-2 virus S protein gene. Applicable age for vaccination is over 18 years old. The number of inoculation doses is 2 doses.
Other components of the vaccine: L-Histidine, L-Histidine hydrochloride monohydrate, magnesium chloride, polysorbate 80 (Polysorbate 80), ethanol, sucrose, sodium chloride, disodium ethylenediaminetetraacetic acid (EDTA-2Na).
Common side effects :：pain at the injection site 54.2%, tiredness 53.1%, headache 52.6%, muscle pain 44.0% chills 31.9% arthralgia 26.4% fever (>38 degrees) 7.9% chills 31.9% arthralgia 26.4% fever (>38 degrees) 7.9%
※Other rare reactions: (10-100 people per case) Lumps and vomiting at the inoculation site.
(100-1000 one case human) lymph nodes, loss of appetite, dizziness, abdominal pain
Protection：complete two vaccination, two-administration interval of at least eight weeks, at best 10 to 12 weeks, can prevent 63% ~ 91% have The risk of symptomatic infection. Update on 8/27, about 81% (60% ~ 91%)
莫得納 Moderna is an * mRNA vaccine for SARS-CoV-2 virus spike protein (S protein) . Applicable age for vaccination is over 18 years old. The number of inoculation doses is 2 doses. Number of days between two doses: The Ministry of Health and Welfare recommends at least 28 days.
Other components of the vaccine:lipids {SM-102, polyethylene glycol [PEG] 2000 dimyristylglycerol [DMG], cholesterol, 1,2-distearyl-sn-glycerol-3-phosphocholine (DSPC)}, tromethamine, tromethamine hydrochloride, acetic acid, sodium acetate and sucrose.
Common side effects :：pain at the injection site 84.1%, tiredness 62.9%, headache 55.1%, muscle pain 38.3%, chills 31.9%, arthralgia 23.6%, fever (>38 degrees) 14.2%
※Other rare reactions: (10-100 people per case) erythema at theinjection site, Urticaria, redness. (One case of 100-1000 people) Itching at the inoculation site. (<1000 persons per case) Facial nerve palsy; face swelling
One case of uncommon reactions in 100-1000 people: itching, chills, rash, nasopharyngitis, oropharyngeal pain, palpitations at the vaccination site.
Protection：complete the protective power of 2 doses. 94%* in the next few months .Update on 8/27, 7 days after the completion of 2 doses of inoculation, the protective power is about * 95% ( 90.3% ~ 97.6%)
newly added option at the end of 2021.8 輝瑞 BNT (Pfizer-BioNTech) is an *mRNA vaccine for SARS-CoV-2 virus spike protein (S protein) . Applicable age for vaccination is over 16 years old. The number of inoculation doses is 2 doses. The interval between two doses: 21 days is recommended for the original factory copy, and at least 28 days is recommended by the Ministry of Health and Welfare.
Other components of the vaccine:lipids {(4-hydroxybutyl) azadiyl) bis (hexane-6, 1-diyl) bis (2-hexyl decanoate), 2 [(polyethylene glycol)- 2000] N,N-Ticosylacetamide, 1,2-Distearyl-sn-glycerol-3-phosphocholine} and cholesterol, potassium chloride, potassium dihydrogen phosphate, sodium chloride, Disodium hydrogen phosphate dihydrate and sucrose.
Common side effects :：pain at the injection site 84.1%, tiredness 62.9%, headache 55.1%, muscle pain 38.3%, chills 31.9%, arthralgia 23.6%, fever (>38 degrees) 14.2%
※Other rare reactions: swelling, redness, and nausea at theinjection site. Lymph nodes are swollen and unwell.
: swelling, redness, and nausea at theinjection site. Lymph nodes are swollen and unwell.
Protection：7 days after the completion of 2 doses of inoculation, the protective power is about * 95% (90.3% ~ 97.6%)* in the next few months .
7/27 【高端 MVC COVID-19 Vaccine】Open for the public to choose to use
9/30 Epidemic Command Center Announcement: People over the age of 20 who have not received any vaccines or have received high-end first doses can ask the local health bureau to provide high-end clinics , Directly make an appointment with the clinic for the treatment. (You can also make an appointment on the vaccine willingness registration platform)
高端 MVC COVID-19 Vaccine is an * Protein subunit vaccines . The main genetically engineered modified * spike protein (S protein) as the new crown virus vaccine antigen, can promote the body to produce adequate immune response.
Vaccine features：Lipid antigen technology is transferred from the genetically recombinant virus protein of NIH in the United States, which has high immunogenicity. With a new adjuvant, it can enhance the cellular immune response. High-efficiency process amplification capabilities to meet emergency use needs during pandemics.
→ 高端(Medigen) website
高端新冠肺炎疫苗 (MVC COVID-19 Vaccine) containing *SARS-CoV-2 recombinant spike protein* is a *protein subunit* vaccines for the prevention COVID-19. This vaccine has been manufactured through Taiwan's government approved project. *Over 20 years old* can be vaccinated, 2 doses, 28 days apart.
Other components of the vaccine:Excipients: CpG 1018, Aluminum hydroxide, Phosphate buffer solution.
Common side effects :：injection site pain/tenderness 71.2% soreness/weakness 36% muscle pain 27.6% headache 22.2% diarrhea 15.1% injection site swelling/induration 10.5% nausea/vomiting 7.7% injection site redness 4.9% fever 0.7%
※Other rare reactions：Rare case-facial nerve palsy, high intraocular pressure, may occur frequency <1/1000.
One case of uncommon reactions in 100-1000 people: itching, chills, rash, nasopharyngitis, oropharyngeal pain, palpitations at the vaccination site.
Protection：Compared with other international EUA-approved vaccines, it has been assessed for correlation and meets the protective standards.
10 categories of COVID-19 vaccination order in Taiwan
1. Medical personnel
2. Anti-epidemic personnel of the central and local governments
3. High-risk front-line workers
4. Those who need to go abroad due to special circumstances
5. Maintain the operation of institutions and social welfare care systems
6. Elderly persons over 75 years old (with indigenous people) Those who are 65 years of age or older)
7. Those who maintain national security and the normal functioning of social functions
8. Those who are older than 65 years of age
9. Those who may increase the risk of serious infections and diseases
10. Adults aged 50-64
Are the side effects of the vaccine related to protection?
Introduction to Human Immune System (National Taiwan University Open Course)
What is neutralizing antibody? How are antibodies produced?
What is neutralizing antibody? ( Academia Sinica )
【Doctor Huang ZoNing's Health Lecture】 to understand the protection and resilience of the new crown vaccine, don’t ask which one has the best effect.
The human body's immune system has two parts: innate immunity (non-specific defense) and acquired immunity (highly specific antigen recognition). The side effects after vaccination are usually manifestations of innate immunity. Cells send alarms through chemical substances to notify that foreign bodies have invaded. White blood cells and macrophages are dispatched to eliminate foreign bodies. The body produces inflammation such as swelling, heat, pain or fever. The innate immune response is the first line of defense, which can maintain combat effectiveness for several hours to several days. Acquired immunity is the second line of defense. It takes several days to several weeks to activate. It is a joint attack by T cells and B cells in the lymphatic system to allow the body to produce long-lasting memory adaptive immune responses and antibodies. The next time it will be the same. Invasion of pathogens, acquired immunity will respond quickly.
USA Centers for Disease Control and Prevention (CDC) Weekly / February 26, 2021
US Centers for Disease Control study programs for more than 1.6 million people 2020/12/14 - 2021/1/13 / or Pfizer has applied Modena hit the side effects of the vaccine, the data show * strong or weak innate and acquired immune responses are not necessarily The immune response is related. More than 90% of people have an acquired immune response, but less than 50% have an innate immune response (side effects), and most of them are mild.. In other words, it is not possible to determine whether the body has acquired immune mechanisms based on side effects. Even if there are no adverse reactions, most vaccines are still working.
*相關資訊*
Side effects of the new crown vaccine: BBC reporters personally experienced and explored the scientific reasons
【Doctor Huang ZoNing's Health Lecture】The mRNA vaccine has three differences: manufacturing method, mobility, incidence of side effects and intensity.
The truth about AZ vaccine thrombosis? Side effects of the vaccine after the vaccine – Dr. Jiang Kunjun-Health 2.0
Eating Panadol (Acetaminophen)
, be careful | Pharmacist Chen Yanhong, Department of Pharmacy, Kaixuan Hospital
Nutritionist experts recommend that the diet be supplemented with more prototype foods before and after vaccination
Supplement more water, eat a balanced diet (high-quality protein, nuts, seeds, fats, fruits and vegetables), relax and sleep well.
Nutrients to help immunity(ingest as much as possible from food, and be careful not to overdo it in nutritional food supplements)- Vitamin C, vitamin D, Omega-3, EPA, DHA, amino acids, selenium, zinc, folic acid (vitamin B9), nucleic acid (Nucleic acid)
Foods to help immunity -sunflower seeds, pumpkin seeds, sesame seeds, flax seeds, chia seeds, kelp/green algae/cyanobacteria (spirulina), fish oil, plant-derived mushrooms, eggs, milk, chicken, fish, yogurt Milk, probiotics, cheese, fermented foods (kimchi, miso, natto)
Water/soup/tea/juice – add more water to reduce adverse reactions.
Foods with high nucleic acid content – legumes (soya beans, broad beans, kidney beans, peas, lentils, cowpeas/haricot beans, pinto beans, red beans), green algae, brewer’s yeast, brown rice, buckwheat flour, broccoli, spinach, seafood, fish and shellfish ( Salmon, dried small fish, herring, mussels, mackerel, salmon trout, sardines, cuttlefish), animal offal
Garlic – Rich in organic sulfur compounds, it helps fight bacteria and viruses. Contains Prebiotics to aid digestion and help maintain the function of the digestive tract.
Curcumin / curry . ．Ginger – Regulates physiological functions, nourishes and strengthens the body, and enhances physical strength.
Green vegetables / cruciferous vegetables (spinach, cauliflower, cabbage)* contain minerals and phenolic compounds, which promote metabolism.
Fresh fruits (guava, citrus, kiwi)– containing vitamin C and phytochemicals, can resist oxidation and regulate physiological functions.
Salmon, chicken soup, eggs, milk, soy milk – supplement protein, amino acids, OMEGA-3, nourish and strengthen the body, strengthen physical strength, and help maintain the function of the digestive tract.
Cold pressed olive oil - – contains unsaturated fatty acids to reduce inflammatory factors-such as C-reactive protein
Blueberry – Contains plant flavonoids, polyphenols, anthocyanins, supplements the nutrition of serotonin, reduces blood pressure and relieves anxiety.
Dark chocolate – relaxes and replenishes vitality, helps sleep, and promotes metabolism.
One-time purchase of nutritional products from all over the world: free shipping to Taiwan→Read more
Aromatherapy soothing recommend use hydrosol / hydrolat after vaccination
During the vaccination period, the body will produce protection (B cells/antibodies) and resilience (T cells) to the highest peak in about 2~4 weeks.Protection * means that the body will remember the virus (pathogen) and produce Neutralizing antibodies can be quickly extinguished next time if the infection is re-infected. *Immune Resilience* refers to allowing the body to restore health without becoming severely ill. Doctor Huang ZoNing's video）
Within 2 weeks after the vaccine is given, I recommend not to use essential oil massage, bathing or high-concentration scenting, or sniffing essential oil molecules, so as not to affect the effect of the vaccine and the body's immune response. During this period , it's better * take high-quality balanced diet, relax , and sleep well *, let the body has enough nutrients to produce antibodies. Seek medical attention as soon as possible if there are serious adverse reactions.
Hydrosols are the macromolecules and water-soluble components of aromatic herb plants which are separated and extracted by distillation . These hydrosols , such aslavender, orange blossom, chamomile and linden,* are suitable for external application, aloe vera gel or spray moisturizing during this period. Or use a dry herbs sachet with a mild scent, and drink some herbal teas to make the body feel relaxed and comfortable.
【Related Reading】
Some useful information about COVID-19 prevention 【 COVID-19 overall info 】
Aromatherapy and diet that protect and enhance immune to fight SARS-CoV-2 ( COVID-19 )
《Aromatherapy Notes》Aromatherapy solution and suggestion for COVID-19
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